Prompt Evidence Assessment & Review of the Literature (PEARLs)

Putting together the evidence

In an effort to help health care providers stay informed about new clinical research findings, Alosa Health produces educational outreach tools known as PEARLs. These are designed to give busy practitioners a rapid, clinically relevant summary of important new published papers, studies presented at major conferences, or safety warnings that have the potential to change practice.

PEARLs are distributed electronically as they are published. If you’d like to receive PEARLs please contact us at


Published PEARLs:

Bisphophonates: Do bisphosphonates raise the risk of atypical femur fracture? And even if they do, are they worth using anyway? (September 2012)

Aspirin: Re-assessing aspirin: not so good for primary prevention? (September 2012)

Citalopram: Citalopram increases the QT interval and risk of sudden death (June 2012)

Oral anticoagulants: New and improved? Oral anticoagulants to reduce stroke in atrial fibrillation (February 2012)

Azithromycin: Can an azithro a day keep COPD exacerbation away? (February 2012)


Given the large amount of literature that is regularly produced on a clinical topic, information may become outdated. Therefore, Alosa archives our materials when they are three or more years old. However, certain information about common primary care topics will never change, and as such, we will continue to provide selected archived materials available upon request. Please contact us at for more information.

Archived PEARLs:

Niacin: Bad AIM? A stopped trial raises questions about niacin use (August 2011)

Simvastatin: Rethinking the role of simvastatin: Recent cautions from the FDA (July 2011)

Bronchodilators: Long-acting bronchodilators in COPD: Making the right choice (May 2011)

Rosiglitazone: Now what for patients taking rosiglitazone (Avandia)? (January 2011)

Calcium supplements: Alosa (October 2010)

Proton pump inhibitors: Is there an association between proton pump inhibitors (PPIs) and fractures? (July 2010)

ACCORD trial: Did ACCORD show discord on how to manage BP and lipids in diabetic patients? Not totally. (April 2010)